Cassava haplotype map highlights fixation of deleterious mutations during clonal propagation
نویسندگان
چکیده
منابع مشابه
Fixation of deleterious mutations at critical positions in human proteins.
Deleterious mutations associated with human diseases are predominantly found in conserved positions and positions that are essential for the structure and/or function of proteins. However, these mutations are purged from the human population over time and prevented from being fixed. Contrary to this belief, here I show that high proportions of deleterious amino acid changing mutations are fixed...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2017
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.3845